Endocrine Abstracts

The adrenal cortex synthesizes glucocorticoids that are essential for metabolic homeostasis and modulation of immune responsiveness. Glucocorticoid-producing cells, located in the zona fasciculata (zF), constitute the critical effector of the HPA axis that serves to mediate the mammalian stress response. Dysregulation of glucocorticoid function results in significant morbidity with complete deficiency being incompatible with life. While the zF is composed of heterogenous cell ...